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KMID : 0385019940100020247
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Korean Journal of Laboratory Animal Science
1994 Volume.10 No. 2 p.247 ~ p.252
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Sex Difference in Cephaloridine Nephrotoxicity in Mice
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김영훈/Kim, Young Hoon
김달현/임동문/박관하/정성목/Kim, Dal Hyun/Lim, Dong Moon/Park, Kwan Ha/Jeong, Seong Mok
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Abstract
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The present study was undertaken to elucidate the role of female sex hormone in sex-selective nephrotoxocity of cephaloridine(CER) by using ovariectomized and β-estradiol treated (5ng/mouse) ICR female mice.
All mice used in this experiment were intravenously injected with CER at a dose of 1000㎎/㎏ and examined for nephrotoxity at 48hrs, The CER nephrotoxicity was evaluated by blood urea nitrogen(BUN) concentration, kidney-to-body weight ratio(KW/BW, ㎎/g), and ability of renal cortical slice to accumulate the organic cation, tetraethylammonium(TEA).
Following a single injection of CER, the KW/BW ratio and BUN concentration were markedly increased while the TEA S/M ratio(an indicator of cortical slice accumulation l was decreased by 54.7 in female mice. In contrast, in male mice, the KW/BW ratio and TEA S/M ratio were not changed, BUN concentration being slightly elevated, Therefore, in normal mice, the females are more susceptible than males to CER-induced nephrotoxieity.
The concentration(44.6±24.7㎎/dL) of BUN following CER in ovariectomized/β-estradiol treated group was significantly lower than that(F13.3±64㎎/dL,) of CER-alone group. The TEA S/M ratio was greatly decreased in both CER-alone(41.4%) and ovariectomized groups (49.6%), but slightly decreased in ovariectomized/β-estradiol group(25.6%). These results indicate that female sex hormone has a protective property against CER-induced nephrotoxicity in ovariectomized mice and that the higher susceptibility in female mice to GER nephrotoxicity than in male mice is not due to the female sex hormone.
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KEYWORD
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